Discovery of novel nonsteroidal glucocorticoid receptor modulators

J T Link; Bryan K Sorensen; Jyoti Patel; Maurice Emery; Marlena Grynfarb; Annika Goos-Nilsson

doi:10.1016/j.bmcl.2004.02.013

Discovery of novel nonsteroidal glucocorticoid receptor modulators

Bioorg Med Chem Lett. 2004 May 3;14(9):2209-12. doi: 10.1016/j.bmcl.2004.02.013.

Authors

J T Link¹, Bryan K Sorensen, Jyoti Patel, Maurice Emery, Marlena Grynfarb, Annika Goos-Nilsson

Affiliation

¹ Metabolic Disease Research, Abbott Laboratories, Department 4CB, Bldg. AP-10, Rm. L-14, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. james.link@abbott.com

PMID: 15081010
DOI: 10.1016/j.bmcl.2004.02.013

Abstract

A new class of selective nonsteroidal glucocorticoid receptor modulators typified by N-[3-[benzyl-(4-chloro-2-fluoro-benzyl)-amino]-2-methyl-phenyl]-methanesulfonamide 19 has been discovered.

MeSH terms

Animals
Benzyl Compounds
Humans
Rats
Receptors, Glucocorticoid / drug effects*
Structure-Activity Relationship
Sulfonamides

Substances

Benzyl Compounds
N-(3-(benzyl-(4-chloro-2-fluoro-benzyl)-amino)-2-methyl-phenyl)-methanesulfonamide
Receptors, Glucocorticoid
Sulfonamides